Serological diagnosis of SARS-CoV-2 infections strongly focus on IgG and IgM detection. It is assumed that IgM is the first antibody produced in response to the infection whereas IgG, which is synthesized later but shows enduring presence, has an impact on long-term immunity.…, 2021

In addition to an increased sensitivity, monitoring of the IgA response could provide additional diagnostic value. A recent case study performed with COVID-19 patients in the University Medical Center Hamburg-Eppendorf, Germany identified a connection between disease severity and the SARSCoV- 2 specific IgA response.

These results underline the potential importance to include IgA detection for the serological assessment of COVID-19 patients.



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